Background: Renal transplantation is the best treatment option for the end-stage of renal failure, although it needs some changes in patient lifestyle. The aim was to evaluate the effectiveness of health education program on coping and quality of life (QoL) of kidney recipients. Subject and methods: This study was carried out in the kidney transplantation outpatient clinics at Nasr City Health Insurance Hospital using a quasi-experimental design with pre-post-follow-up assessments. The sample was 77 of patients after one year of the kidney transplantation surgery. The tool included Jalowiec Coping Scale (JCS) and the SF-12v2 health survey to assess the Quality of Life. The researchers designed the health education program based on needs assessment, and implemented it in small groups sessions their numbers 11 group and each group contain 7 patients, twice per week. The effect was evaluated immediate post test and at 3-month follow-up. The work lasted January to August 2014.  Results:  The mean score of the emotional element of Jalowiec scale increased at the follow-up phase reaching 67.8 compared with 65.4 at the pre-intervention phase (p=0.01). Coping and QoL scores were inter-correlated weakly to moderately at the three phases, while the history of previous surgery was a significant positive predictor of Jalowiec emotional score, For mental QoL Jalowiec confrontive score was a significant negative predictor, whereas having a chronic disease and the score of emotional Jalowiec were significant positive predictors of the physical QoL score, and the working state, previous surgery, and the Jalowiec confrontive score were negative predictors. Conclusion, the educational intervention has a significant positive effect on patients' emotional coping, but not on their QoL. The recommendation implementing the program after modifications to give more focus on the use of various coping strategies, with longer follow-up evaluation.