Background: Stroke is the third most common cause of death worldwide and the leading cause of adult disability. Aim of the study: was to assess the impact of a nursing education program on Knowledge among patients at risk for stroke. Subjects and Method: A quasi-experimental design was used in the current study. This study was carried out on a convenient sample of 133 patients at risk of stroke. This study was conductedin the outpatients clinics in governmental hospitals and the health insurance hospitals in Port-Said City. Three different tools were used for data collection, namely 1) -Structured interview questionnaire sheet , 2) -  Stroke risk assessment screening tool and 3) - Patients'  assessment knowledge about stroke. The educational program was designed based on an extensive revision of the related materials, recent medical surgical nursing textbooks, studies and literature. Results: The study results revealed that very high statistical significant difference in total and sub-items scores of  studied patients' knowledge were found  between before and immediately after program implementation and between before and 3months after program implementation, slightly decline was evident in total patient knowledge from post immediate and post 3 months after the program implementation(99.2% to 96.2%) respectively ,but it was still higher than before program implementation(6.0%).Conclusion: The study concluded that The knowledge was significantly improved after implementation of nursing educational program about stroke prevention. Recommendations: The study recommended thatregular continuouseducation programs should be conducted in the different outpatient clinics providing medical care for patients at risk for stroke to give information about stroke prevention for enhancing knowledge.