Background: Intestinal parasitic infection in children is one of the most urgent problems during toddler and preschool stage of life. This period represents a challenge to the family and community and need greater attention to deal with this big problem. Nursing management plan include health education is important to improve the mother's knowledge and hygienic practices to prevent intestinal parasitic infection. .Aim: This study aimed at designing, implementing and evaluating the effect of a nursing management plan (NMP) for children who suffer from intestinal parasitic infection and their mothers at primary health care centers. Subject and Method:  A sample of 230 children are from one to five years suffering from intestinal parasites infection and their mothers in study settings and 230 control.  Conclusion: The study was conducted at seven primary health care centers in Port Said city. Data were collected usingchildren's medical record, pre designed questionnaire for mothers, an interviewing questionnaire for nurses and Likert types rating scale for children's attitude. Results: The results of the present study indicated that, E. histolytica and E. vermicularis were the most common intestinal parasitic infection in children in both study and control groups. According to the mother's knowledge, it was found that all mother's knowledge highly improved among study group from pre to post implementation of NMP. As regards reported mothers' practice, more than half of mother's total practice in study and control groups have inadequate practice related to pre-implementation of NMP. On the other hand, more than half of study and control groups have adequate practice in relation to post implementation of NMP. Recommendations: The research recommended that a well-planned prevention and control program, taking into account the personal and environmental risk factors at the household and/or community level is a necessary and important measure for solving the problem, especially in such low-resource areas.