Background: Emergency contraceptive pills (ECPs) are important resource with excellent potential to further reduce the number of unwanted pregnancy and abortion. Therefore, this study.Aim: aims to assess and evaluate the impact of an educational program on nurse's knowledge toward using ECPs. Subjects and methods: a quasi-experimental intervention study for nurses were used in this study. 27 maternity nurses were selected convenience for the intervention part of this study. The data were collected through the period of seven months.  The researcher used self-administrated questionnaire tools for the nurses.Results: The results revealed that: nurses had deficient knowledge on ECPs (7.4%) at the pre-program phase while after implementation of nursing educational program there are a statistically significant improvement in nurse's knowledge at post and follow-up phases was showed. Conclusion: significant improvement of nurse's knowledge was shown after the implementation of the educational program. Recommendations: family planning counseling by the maternity nurse including ECPs must be emphasized as an integral part of any family planning activities and programs, continuous refreshing courses about ECPs for nurses including the newly appointed nurses as well as regular supervision and evaluation of nurse's performance. On the other hand, hotlines should be developed to provide information about emergency contraceptives and referrals to clinics that provide these services.