Background: the dynamic health care system requires newly graduate nurses who can collect pertinent data, access to resources, prioritize the information, solve the problems, and ultimately make sound clinical decisions. Aim: to study the relationship between clinical decision making with critical thinking dispositions among students at faculty of nursing in Port- Said University.Subject and Methods: The Research design was a co-relational descriptive design.  Setting the study setting was conducted at the Faculty of Nursing, Port Said University.  Subject: Consisted of all (155) nursing students who were regular attendants at the third and fourth academic year at Faculty of Nursing in Port- Said University.  Tools of data collection: Two tools were used for data collection.  I) Clinical decision making nursing scale.  II) California critical thinking disposition inventory. Results: The study results revealed that, the second dimension canvass for objectives and values scored the highest mean (36.26) clinical decision making. The nursing students had high ability in total clinical decision making, while has the highest mean score for critical thinking characteristics was inquisitiveness for nursing students, followed by analyticity among nursing students, as well as followed by self-confidence among nursing students. However, the lowest mean score was in truth seeking for nursing students. Nursing students had a moderate level of the critical thinking disposition .Conclusion: there was no statistical significant correlation between, Critical thinking disposition of nursing student, although there is a statistical significant correlation among some dimensions of these variables.Recommendations: the study recommended that nursing educational programs need to be revised for the inclusion of resources needed to implement critical thinking to nursing students and continuous training for nursing educator and students about CT whether the theory and practice and how to evaluate its dispositions effectively and  starting early when student admission.