The present study will designe to explore the biological effects of gum arabic (GA) on kidney disorders induced by arginine in rats. Also, the addition of GA to low protein diet (LPD), one of an important kidney disorders treatment, in a trial to add some positive biological effects to the kidney patients will be in the scope of this study. The obtained data revealed that The mean value of uric acid and creatinine of the negative control group fed on basal diet was 1.73 and 0,80 mg.dl-1 , while uric acid and creatinine of group fed on BD containing 2% arginine (Control +ve) was 2.91 and 1.79 mg.dl-1 , respectively. The rate of increasing in uric acid and creatinine as the result of kidney disorders induction was 68.28 and 124.15%. Additional of groups fed on GA and low protein diet (LPD) containing 2% arginine and led to decrease uric acid and creatinine by different rates. Co-treatment group fed on GA and LPD exhibited synergistic effect and recorded the highest decreasing rate in uric acid and creatinine (-19.99 and -21.15%, respectively). Also, the same behavior was recorded for serum mineral content (Na and K) and malondialdehyde content (MDA), the biomarkers of oxidative stress and inflammation in the body. In conclusion, we recommended to pay more attention in the future to carry out more research in the area of GA and extended its applications in human diets, industrial and medical applications .