Abstract: The present study aims to investigate the effect of three plant parts extract [Okra fruits water extract (OFWE), White mulberry leaves water extract (MLWE), Celery leaves water extract (CLWE) and their Mixture in modulating the serum hyperglycemia using alloxan-induced diabetic rat model. The date revealed that treatment of animals with alloxancaused a significant increased (p≤0.05) in serum glucose concentration by the ratio 136.51% compared to normal animals (negative control group). Supplementation of the rat diets with 2% w/w by OFWE, MLWE, CLWE and their mixture decreased this elevation value compared to normal controls and recorded 57.35, 38.69, 52.27 and 35.48%, respectively. The maximum hypoglycemic yield was recorded for the extracts mixture treatment when compared with the rest selected plant parts extracts individually. Beside the hypoglycemic effect was observed by the selected plant extracts high significant (p≤0.05) improvements were exhibited for liver and kidney functions as well as serum lipid profile. In conclusion, the data of the present work with that carried out by the others could be represent the mile stone towards the extension of using plant parts extracts such MLWE, CLWE, OFWE and their mixture as natural antioxidants in many different medical applications such improve the serum glucose level, liver and kidney functions as well as blood lipid profile.