Over the past few years, entrepreneurship in Egypt has received more attention, and through this interest the number of Egyptians seeking entrepreneurial opportunities has increased, and since individuals are the ones responsible for entrepreneurial activities. It was important to investigate and find out if a gender difference could have an impact on the effectiveness of entrepreneurship. This study aimed to provide information and explore whether gender differences can have an impact on the effectiveness of entrepreneurship in small and medium sized enterprises. By focusing on various factors such as age, education, previous experience, in addition to interpersonal skills, goal attainment and business growth. Since females are less likely than males to participate in entrepreneurship activities - which negatively affects the greater integration of females into the labor market and the start of their own businesses - results showed that the gender of entrepreneur had no effect on profit growth, increase in employment, technology skills or goal attainment. While the gender of entrepreneur had an effect on growth in sales, interpersonal skills and business skills.