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189019

SYNTHESIS OF NEW CONDENSED PYRIMIDINES: I

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Last updated: 22 Jan 2023

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Abstract

2-Dicyanomethylidinoindoline (I) obtained from lactime ether of  oxindole and malononitrile, when added to various isocyanates or isothiocyanates afforded 2-alkye-3-imino-1-oxo or thioxo-1,2,3,4,4a,5-hexahydro-pyrimido1,6-alindole-4-carbonitrile. The corresponding enaminonitriles were obtained by reduction with sodium borohydride. Álkylation and hydrolysis of the prepared compounds are also described .

DOI

10.21608/zjps.1992.189019

Authors

First Name

Mohamed

Last Name

Ebeid

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt

Email

mohamed.ebeid@yahoo.com

City

-

Orcid

-

First Name

Sayed

Last Name

Lashine

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt

Email

smlashine@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Abdalla

Last Name

El-Shanawani

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

Email

aael-shanawani@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Mansour

Last Name

Abou-Kull

MiddleName

-

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt

Email

meabou-kull@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

N.

Last Name

Abou Taleb

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, university of Cairo, Egypt .

Email

n.abou-taleb@yahoo.com

City

-

Orcid

-

Volume

1

Article Issue

1

Related Issue

24777

Issue Date

1992-06-01

Receive Date

1992-03-03

Publish Date

1992-06-01

Page Start

43

Page End

54

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 1_Issue 1_Pages 43-54.pdf

PDF . 5.3MB

Link

https://zjps.journals.ekb.eg/article_189019.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=189019

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Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

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Article

Created At

22 Jan 2023