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187364

SYNTHESIS OF CERTAIN SUBSTITUTED 7-CHLORO-4- QUINAZOLONES OF PHARMACEUTICAL INTEREST

Article

Last updated: 22 Jan 2023

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Abstract

The synthesis of some N-(7-chioro-3-phenyl-4 (3H)-quinazolinon-2-ylmercaptoacetyi) hydrazones is described. Reacting 7-chloro-3-phenyl-4-quinazolinone-2-thione with ethyl chloroacetate yielded two isomeric esters. Condensation of these esters with hydrazine hydrate under different reaction conditions afforded the expected hydrazides in addition to some sulphur free products.

DOI

10.21608/zjps.1993.187364

Authors

First Name

Mohamed

Last Name

Al-Ashmawi

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

mial-ashmawi@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Shabaan

MiddleName

-

Affiliation

Department of Organic Chemistry, Faculty of Pharmacy, Cairo University

Email

mohamed.shabaan@yahoo.com

City

-

Orcid

-

First Name

Refaat

Last Name

Omar

MiddleName

-

Affiliation

Department of Organic Chemistry, Faculty of Pharmacy, Cairo University

Email

refaat.omar@yahoo.com

City

-

Orcid

-

Volume

2

Article Issue

2

Related Issue

24776

Issue Date

1993-12-01

Receive Date

1993-10-04

Publish Date

1993-12-01

Page Start

158

Page End

168

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 2_Issue 2_Pages 158-168.pdf

PDF . 4.7MB

Link

https://zjps.journals.ekb.eg/article_187364.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=187364

Order

15

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

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Article

Created At

22 Jan 2023