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187359

PHARMACOLOGICAL EVALUATION OF TOLTRAZURIL WITH SPECIAL REFERENCE TO ITS ADVERSE EFFECTS

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Last updated: 22 Jan 2023

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Abstract

Toltrazuril which is a novel anticoccidial agent elicit an inhibitory effect on the isolated smooth muscles of both intestine and oviduct of chicken. It was proved that its effect is due to an antihistamine-like effect. Toltrazuril exerted a negative inotropic effect on isolated chicken's heart with a decrease in coronary outflow. The drug induced hypotension with increased respiratory rate. Moreover, oral adminstration of toltrazuril produced a significant increase in serum GOT, glucose, creatinine and uric acid. The drug elicited a significant decrease in serum GPT, total protein and cholesterol levels. Histopathological findings were discussed.

DOI

10.21608/zjps.1993.187359

Authors

First Name

Mostafa

Last Name

Abd El Aziz

MiddleName

-

Affiliation

Department. of pharmacology, Faculty of Veterinary Medicine, Zagazig University.

Email

mostafa.abdel-aziz@yahoo.com

City

-

Orcid

-

First Name

Sabri

Last Name

Abdel-Motal

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Vet. Med., Zagazig University, Egypt.

Email

sabri.abdel-motal@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Khairy

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Egypt.

Email

mohamed.khairy@yahoo.com

City

-

Orcid

-

First Name

Ashour

Last Name

El-Gammal

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Vet. Med., Zagazig University, Egypt.

Email

ashour.el-gammal@yahoo.com

City

-

Orcid

-

First Name

Gamal

Last Name

Shams

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Vet. Med., Zagazig University, Egypt

Email

gamal.shams@yahoo.com

City

-

Orcid

-

First Name

Abdel-Alem

Last Name

Fouad

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Vet. Med., Zagazig University, Egypt.

Email

abdel-alem.fouad@yahoo.com

City

-

Orcid

-

First Name

Elene

Last Name

Mankarios

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Vet. Med., Zagazig University, Egypt.

Email

elene.mankarios@yahoo.com

City

-

Orcid

-

Volume

2

Article Issue

2

Related Issue

24776

Issue Date

1993-12-01

Receive Date

1993-09-04

Publish Date

1993-12-01

Page Start

117

Page End

129

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 2_Issue 2_Pages 117-129.pdf

PDF . 5.7MB

Link

https://zjps.journals.ekb.eg/article_187359.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=187359

Order

11

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

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Article

Created At

22 Jan 2023