Beta
ManageSearchChatDiscover
187356

DESIGN AND SYNTHESIS OF A PIPERAZINE DERIVATIVE AS A HIGH AFFINITY 5-HTIA RECEPTOR LIGAND

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Serotonin (5-HT) 1A receptors have been shown to have physiological, biochemical pharmacological and clinical values. The piperazino derivative 1 was rationally designed as a bulky, lipophilic N4-substituted arylpiperazine. Radioligand binding assay of 1 at 5-HT1A receptors indicates that it binds at these receptors with higher affinity than the famous 5-HT1A, ligand, buspirone (Ki = 15 nM). Buspirone is currently used to treat anxiety.

DOI

10.21608/zjps.1993.187356

Authors

First Name

Mohamed

Last Name

El-Bermawy

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

mael-bermawy@pharmacy.zu.edu.eg

City

-

Orcid

-

Volume

2

Article Issue

2

Related Issue

24776

Issue Date

1993-12-01

Receive Date

1993-08-12

Publish Date

1993-12-01

Page Start

103

Page End

110

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 2_Issue 2_Pages 103-110.pdf

PDF . 3.8MB

Link

https://zjps.journals.ekb.eg/article_187356.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=187356

Order

9

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023