Daily oral doses (400 mg/kg.b.wt.) of the lyophilized aqueous extract of C. verbascifolia were given to adult Wistar rats for a period of 4 weeks. The results revealed a significant decrease in cholesterol level (P<0.05) and inorganic phosphorus (P < 0.001), in addition to a marked increase (P < 0.001) in serum albumin and calcium. The haemogram showed a marked leucocytopenia, lymphocytopenia, decreased neutrophils, monocytes (P < 0.001) and basophils counts (P<0.05). Moreover, a significant increase (P<0.01) in MCH was also recorded. Changes in body and organ weights as well as histopathological findings were also discussed.