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188988

SYNTHESIS OF SOME 1,3,4- OXADIAZOLES FROM ETHYL IMIDAZO [4,5-B] PYRIDINYL PROPIONATE AS PONTENTIAL ANTIINFLAMMATORY AGENTS

Article

Last updated: 04 Jan 2025

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Abstract

Synthesis of 2- (6-bromo -2- imidazo  [4,5-b] pyridinyl) ethyl -5-( substituted) thío 1,3,4 Oxadiazole derivatives is described. The preparation of 1,3,4 - Oxadiazoles was achieved by cyclization of the corresponding acid hydrazide. Mannich reaction was applied on these new oxadiazoles giving the corresponding Mannich bases .Two of the prepared compounds were tested for their analgesic, antipyritic and antiinflammatory activities to show promising effects.

DOI

10.21608/zjps.1993.188988

Authors

First Name

Mohamed

Last Name

Ebeid

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt

Email

mohamed.ebeid@yahoo.com

City

-

Orcid

-

First Name

Sayed

Last Name

Lashine

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt

Email

smlashine@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Nageh

Last Name

Abou Taleb

MiddleName

-

Affiliation

FACULTY OF PHARMACY, CAIRO UNIVERSITY

Email

nageh.abou-taleb@yahoo.com

City

-

Orcid

-

First Name

Lobna

Last Name

Abdel-Aziz

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt

Email

lmabdel-aziz@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Magdy

Last Name

Amer

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, University of Mansoura, Egypt.

Email

magdy.amer@yahoo.com

City

-

Orcid

-

Volume

2

Article Issue

1

Related Issue

24775

Issue Date

1993-06-01

Receive Date

1993-03-01

Publish Date

1993-06-01

Page Start

62

Page End

72

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 2_Issue 1_Pages 62-72.pdf

PDF . 5.0MB

Link

https://zjps.journals.ekb.eg/article_188988.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=188988

Order

6

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

MainTitle

SYNTHESIS OF SOME 1,3,4- OXADIAZOLES FROM ETHYL IMIDAZO [4,5-B] PYRIDINYL PROPIONATE AS PONTENTIAL ANTIINFLAMMATORY AGENTS

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Type

Article

Created At

22 Jan 2023