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186443

ESSENTIAL OIL AND LIPIDS OF NIGELLA SATIVA SEED AND THEIR BIOLOGICAL ACTIVITY

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Last updated: 22 Jan 2023

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Abstract

The essential oil as well as the expressed oil of Nigella sativa L. seeds, were subjected to qualitative and quantitative studies employing different chromatographic techniques. Thymoquinone (ca 30%), p-cymene (ca 38%) and a-pinene (ca 14%) constituted the main make up of the essential oil. GLC revealed that the lipid portion of the expressed oil iss built-up mostly of stearic (ca 47%) and arachidic (ca 32%) acids beside lesser amounts of palmitic (ca 7%) and myristic (ca 4%) acids. a-amyrin, B-sitosterol and oleanolic acid were isolated from the unsaponifiable matter of the lipid portion. The expressed oil showed significant antimicrobial and antifungal activities. It could normalized the enzymatic disturbance in the liver tissue, previously produced by exposure to ionizing radiation. This radioprotective effect was supported by the morphological changes of liver tissues. The intestine showed minimal changes and no evidence of protection was observed for the kidneys.

DOI

10.21608/zjps.1994.186443

Authors

First Name

Mohamed

Last Name

Karawya

MiddleName

-

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

mohamed.karawya@yahoo.com

City

-

Orcid

-

First Name

Fayek

Last Name

Hashim

MiddleName

-

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

fayek.hashim@yahoo.com

City

-

Orcid

-

First Name

Samia

Last Name

Abd El-Wahab

MiddleName

-

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

samia.abd-el-wahab@yahoo.com

City

-

Orcid

-

First Name

Kadriya

Last Name

EI-Deeb

MiddleName

-

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

kadriya.ei-deeb@yahoo.com

City

-

Orcid

-

First Name

Suzan

Last Name

Soliman

MiddleName

-

Affiliation

Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

suzan.soliman@yahoo.com

City

-

Orcid

-

First Name

Ibrahim

Last Name

Salam

MiddleName

-

Affiliation

Cancer Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt

Email

ibrahim.salam@yahoo.com

City

-

Orcid

-

First Name

Nadia

Last Name

Mokhtar

MiddleName

-

Affiliation

Histopathology Department, National Cancer Institute, Cairo University, Cairo, Egypt

Email

nadia.mokhtar@yahoo.com

City

-

Orcid

-

First Name

Somaya

Last Name

El-Hossiny

MiddleName

-

Affiliation

Histopathology Department, National Cancer Institute, Cairo University, Cairo, Egypt

Email

somaya.el-hossiny@yahoo.com

City

-

Orcid

-

Volume

3

Article Issue

2

Related Issue

24774

Issue Date

1994-12-01

Receive Date

1994-07-05

Publish Date

1994-12-01

Page Start

49

Page End

57

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 3_Issue 2_Pages 49-57.pdf

PDF . 5.5MB

Link

https://zjps.journals.ekb.eg/article_186443.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=186443

Order

6

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

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-

Details

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Article

Created At

22 Jan 2023