Beta
ManageSearchChatDiscover
186442

SYNTHESIS OF SOME PYRIMIDO-[1,6-a]- INDOLE OF POTENTIAL PHARMACOLOGICAL INTEREST

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

The synthesis of some pyrimido-[1,6-a]- indole derivatives is described. Addition of dicyanomethylideneindoline (I) to various isocyanates gave 2-alkyl-3-imino-1-oxo-1,2,3,5- tetrahydropyrimido-[1,6-a]- indole-4-carbonitrile lla-h. The corresponding enaminonitriles Illa-h were obtained from II by reduction with sodium borohydride. Compounds IV-VIl were also obtained. Preliminary pharmacological screening revealed antipyretic, antiinflammatory and analgesic activities.

DOI

10.21608/zjps.1994.186442

Authors

First Name

Mohamed

Last Name

Ebeid

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt

Email

mohamed.ebeid@yahoo.com

City

-

Orcid

-

First Name

Sayed

Last Name

Lashine

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt

Email

smlashine@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Sobhy

Last Name

El-Adl

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt

Email

smel-adl@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Mansour

Last Name

Abou-Kull

MiddleName

-

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt

Email

meabou-kull@pharmacy.zu.edu.eg

City

-

Orcid

-

Volume

3

Article Issue

2

Related Issue

24774

Issue Date

1994-12-01

Receive Date

1994-07-02

Publish Date

1994-12-01

Page Start

40

Page End

48

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 3_Issue 2_Pages 40-48.pdf

PDF . 3.9MB

Link

https://zjps.journals.ekb.eg/article_186442.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=186442

Order

5

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023