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186740

STRUCTURE-ACTIVITY INVESTIGATION OF ATYPICAL ACRIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS

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Last updated: 04 Jan 2025

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Abstract

Although acridines and many tricylic compounds are known to possess potent antimicrobial activity, yet most of these compounds are either toxic (cannot be used systemically) or have other pharmacological activities. To develop safe and effective agents, we report the design and synthesis of nonclassical acridine derivatives. Biological evaluation of these acridine analogues showed a consistent structure-activity relationship. Some of these acridines showed potent antimicrobial activity, compound 22 exhibited MIC of 7 ug / mL.

DOI

10.21608/zjps.1994.186740

Authors

First Name

Mohamed

Last Name

Al-Ashmawi

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

mial-ashmawi@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

El-Sadek

MiddleName

-

Affiliation

Dept. of Medicinal Chemistry, Faculty of Pharmacy, University of Zagazig, Zagazig , Egypt

Email

meel-sadek@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

El-Bermawy

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

mael-bermawy@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Ashraf

Last Name

Kadry

MiddleName

-

Affiliation

Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University

Email

aakadry@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Osama

Last Name

Al-Sabbagh

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Egypt

Email

oial-sabbagh@pharmacy.zu.edu.eg

City

-

Orcid

-

Volume

3

Article Issue

1

Related Issue

24773

Issue Date

1994-06-01

Receive Date

2021-08-01

Publish Date

1994-06-01

Page Start

144

Page End

150

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 3_Issue 1_Pages 144-150.pdf

PDF . 3.5MB

Link

https://zjps.journals.ekb.eg/article_186740.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=186740

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Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

MainTitle

STRUCTURE-ACTIVITY INVESTIGATION OF ATYPICAL ACRIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS

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Article

Created At

22 Jan 2023