Cadmium chloride (0.5 mg/kg) was given intraperitoneally (i.p.) into mature male rabbits every other day for 5 weeks. The results showed a significant increase in serum total proteins. An increase in β and ɣ-globulins (P < 0.001) was observed. Serum ALT and AST activities were also increased in rabbits treated with cadmium and vaccinated with Clostridia antisera when compared with the vaccinated control group. Whereas, a globulins and serum urea nitrogen (SUN) were significantly decreased (P < 0.001). Blood gases analysis showed significant decreases (P < 0.05) in PCO₂, HCO₃ and TCO₂ in the vaccinated treated group compared with the vaccinated control group. A marked increase (P < 0.001) was also recorded in eosinophils and monocytes counts of the vaccinated treated group compared with the vaccinated control group.