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186709

UTILITY OF DERIVATIVE SPECTROPHOTOMETRY FOR THE DETERMINATION OF FLUOROURACIL IN COMBINATION WITH ITS ALKALI - INDUCED DEGRADATION PRODUCTS

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Last updated: 04 Jan 2025

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Abstract

A simple, rapid and direct spectrophotometric method for the determination of fluorouracil in presence of its alkali-induced degradation products is presented. The method is based on measuring the absolute value of 1D and 2D of the absorption curve at the chosen wavelengths. The validity of the method was confirmed using laboratory prepared mixtures of the intact drug with its alkali-induced degradation products. The method has been also applied for the assay of some pharmaceutical preparations. Moreover, alkaline degradations has been studied and a derivative spectrophotometric method for quantitative determination of these degradations, even in presence of the intact molecule is presented.

DOI

10.21608/zjps.1994.186709

Authors

First Name

Hesham

Last Name

Salem

MiddleName

-

Affiliation

Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

hesham.salem@yahoo.com

City

-

Orcid

-

First Name

Magda

Last Name

El-Maamli

MiddleName

-

Affiliation

Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

mmel-maamli@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

El-Sadek

MiddleName

-

Affiliation

Dept. of Medicinal Chemistry, Faculty of Pharmacy, University of Zagazig, Zagazig , Egypt

Email

meel-sadek@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Afaf

Last Name

Aboul Kheir

MiddleName

-

Affiliation

Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

amaboul-kheir@pharmacy.zu.edu.eg

City

-

Orcid

-

Volume

3

Article Issue

1

Related Issue

24773

Issue Date

1994-06-01

Receive Date

1994-03-20

Publish Date

1994-06-01

Page Start

115

Page End

122

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 3_Issue 1_Pages 115-122.pdf

PDF . 4.3MB

Link

https://zjps.journals.ekb.eg/article_186709.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=186709

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16

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

MainTitle

UTILITY OF DERIVATIVE SPECTROPHOTOMETRY FOR THE DETERMINATION OF FLUOROURACIL IN COMBINATION WITH ITS ALKALI - INDUCED DEGRADATION PRODUCTS

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Article

Created At

22 Jan 2023