Manganus chloride (2 mg/kg b.wt.) was given every other day intraperitoneally (i.p.) for a period of 5 weeks to mature male rabbits. Rabbits were challenged with Clostridia antisera as a stress factor. The results indicated significant elevation in the levels of ß and y-globulins (P < 0.001), serum ALT and AST activities (P< 0.01) and significant decrease in the levels of a-globulins and urea (SUN) (P < 0.001). The blood picture was not significantly changed except for eosinophils and monocytes counts which showed a marked increase and decrease (P <0.001) respectively. Whereas, a moderate increase (P < 0.05) was recorded in PO₂, O₂ SAT% and O₂-CT% of the blood. This study represents the hazardous effect of prolonged exposure to manganus chloide in both histotoxic anoxia and liver dysfunction.