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186601

STEREOSELECTIVE REACTION BETWEEN ACETANTHRANIL AND RACEMIC AMINE

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Last updated: 04 Jan 2025

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Abstract

Racemic amines 1-phenyl-ethylamine and 1-amino-2-propanol were found to undergo kinetic resolution in the stereoselective reaction with acetanthranil. The residual amines have optical rotation of (+) 5.2° and (+) 4.5° which correspond to optical purity of about 15.7% and 18% for 1-phenylethylamine and 1-amino-2-propanol, respectively. The effect of temperature, reaction time, solvent, concentration of amine and catalyst were examined on the kinetic resolution.

DOI

10.21608/zjps.1994.186601

Authors

First Name

Nabaweya

Last Name

Sharaf El-Din

MiddleName

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Affiliation

Departments of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tanta, Tanta, Egypt

Email

nabaweya.sharaf-el-din@yahoo.com

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Orcid

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Volume

3

Article Issue

1

Related Issue

24773

Issue Date

1994-06-01

Receive Date

2021-08-01

Publish Date

1994-06-01

Page Start

35

Page End

39

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 3_Issue 1_Pages 35-39.pdf

PDF . 2.1MB

Link

https://zjps.journals.ekb.eg/article_186601.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=186601

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Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

MainTitle

STEREOSELECTIVE REACTION BETWEEN ACETANTHRANIL AND RACEMIC AMINE

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Article

Created At

22 Jan 2023