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186595

REACTIONS OF 2,3-DICHLOROMALEIC ANHYDRIDE(1): II REACTIONS WITH BINUCLEOPHILES (4+2CYCLOCONDENSATION) FOR SYNTHESIS OF COMPOUNDS WITH POTENTIAL ANTIMICROBIAL ACTIVITY

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Last updated: 04 Jan 2025

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Abstract

The reaction of 2,3-dichloromaleimides 1a-f with binucleophiles, viz, o-aminophenol (2a) and o-phenylenediamine (2b) is described. Products isolated were dependent on both pH and the used reaction solvents. Many of the novel, fused pyrroloquinoxalines and maleimides showed remarkable antimicrobial activities.

DOI

10.21608/zjps.1994.186595

Authors

First Name

Mohamed

Last Name

Al-Ashmawi

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

mial-ashmawi@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Werner

Last Name

Meise

MiddleName

-

Affiliation

Pharmazeutisches Institute der Universitaet Bonn, Kreuzbergweg 26, D-5300 Bonn 1, Germany

Email

werner.meise@yahoo.com

City

-

Orcid

-

First Name

Abdel-Halim

Last Name

El-Sayed

MiddleName

-

Affiliation

Department of Microbiology, Faculty of Pharmacy, Zagazig University, Egypt

Email

abdel-halim.el-sayed@yahoo.com

City

-

Orcid

-

First Name

El-Sayed

Last Name

Lashine

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

emlashine@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Mansour

Last Name

Abou-Kull

MiddleName

-

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt

Email

meabou-kull@pharmacy.zu.edu.eg

City

-

Orcid

-

Volume

3

Article Issue

1

Related Issue

24773

Issue Date

1994-06-01

Receive Date

1994-01-06

Publish Date

1994-06-01

Page Start

8

Page End

19

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 3_Issue 1_Pages 8-19.pdf

PDF . 6.9MB

Link

https://zjps.journals.ekb.eg/article_186595.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=186595

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2

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

MainTitle

REACTIONS OF 2,3-DICHLOROMALEIC ANHYDRIDE(1): II REACTIONS WITH BINUCLEOPHILES (4+2CYCLOCONDENSATION) FOR SYNTHESIS OF COMPOUNDS WITH POTENTIAL ANTIMICROBIAL ACTIVITY

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Article

Created At

22 Jan 2023