Silica gel column chromatography of the butanolic extract of the aeria! parts of Atriplex leucoclada (Family chenopodiaceae) afforded five triterpenoidal saponins. Their structures have been established using spectroscopic methods and hydrolysis followed by identification of the aglycones and sugar moieties. The five saponins were found to possess molluscicidal activities with LC99 values of 6,10,18,12, and 30 ppm, respectively against Schistosomiasis transmitting snail Biomphalaria alexandrina.