The present investigation is an attempt to study the hazardous effects associated with the use of the rodenticide zinc phosphide (Zn₃,P₂) in the albino rats as a useful model for man. The LD₅₀ of Zn₃, P₂ 205 mg/kg b.wt. caused a significant decrease (P < 0.05) of serum glucose and a highly significant decreases (P < 0.01) in liver and muscle glycogen. Total lipid contents, total protein contents, Aspartate amino transferase (AST) and Alanine aminotransferase (ALT) activities showed a great alterations. The sublethal dose of Zn₃ P₂ (102.5 mg/kd b.wt.) elicited a great deteriorations in all the above mentioned parameters in serum, liver and muscles. These deteriorating effects of Zn₃ P₂  may extend to the sixth day after its administration. Thus, the toxic effect of the rodenticide is not limited to the target animals, so it should be empolyed with a great care in rodent control.