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186332

EFFECT OF MORPHINE SULPHATE ON THE STRESS RESPONSE TO IMMOBILIZATION IN RATS

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Last updated: 22 Jan 2023

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Abstract

The effects of peripheral administration of morphine on some haematological parameters and hormone secretion (prolactin and cortisol) were investigated in non-stressed and immobilized rats. Intramuscular injection of morphine sulphate at a dose of 15 mg/Kg body weight, decreased red blood corpuscles (RBCS) count and packed cell volume (PCV) and increased plasma prolactin concentration. Immobilization of rats for 4 hours daily for 4 successive days, induced a marked decrease in PCV value and double fold increase in plasma prolactin and cortisol concentrations. Pretreatment of immobilized rats with morphine sulphate caused a significant decrease in RBCS count, PCV, haemoglobin and plasma cortisol concentration. It was concluded that administration of morphine sulphate to stressed rats adversely affect the haematological picture and partially decrease the adrenal gland response to stressor.

DOI

10.21608/zjps.1995.186332

Authors

First Name

Abdel-Dayem

Last Name

Zakaria

MiddleName

-

Affiliation

Department. Physiology, Faculty of Veterinary Medicine, University of Alexandria, Egypt.

Email

abdel-dayem.zakaria@yahoo.com

City

-

Orcid

-

First Name

Abdel-Hasseb

Last Name

Fayed

MiddleName

-

Affiliation

Department. Physiology, Faculty of Veterinary Medicine, University of Alexandria, Egypt.

Email

abdel-hasseb.fayed@yahoo.com

City

-

Orcid

-

First Name

Sobhy

Last Name

Hedaya

MiddleName

-

Affiliation

Department. Physiology, Faculty of Veterinary Medicine, University of Alexandria, Egypt.

Email

sobhy.hedaya@yahoo.com

City

-

Orcid

-

First Name

Mohy-eldin

Last Name

Mohammed

MiddleName

-

Affiliation

Department. Physiology Faculty of Veterinary Medicine, University of Alexandria, Egypt.

Email

mohy-eldin.mohammed@yahoo.com

City

-

Orcid

-

First Name

Ibrahim

Last Name

El-Ashmawy

MiddleName

-

Affiliation

Department. Pharmacology, Faculty of Veterinary Medicine, University of Alexandria, Egypt.

Email

ibrahim.el-ashmawy@yahoo.com

City

-

Orcid

-

Volume

4

Article Issue

1

Related Issue

24771

Issue Date

1995-06-01

Receive Date

1995-02-10

Publish Date

1995-06-01

Page Start

43

Page End

46

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 4_Issue 1_Pages 43-46.pdf

PDF . 2.4MB

Link

https://zjps.journals.ekb.eg/article_186332.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=186332

Order

6

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

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Article

Created At

22 Jan 2023