The efficacy of Ectomin® 100 E. C. ( Cypermethrin) on naturally occurring Sarcoptes scabiei var ovis ( Sarcoptic nange infected sheep ) was evaluated clinical and parasitological responses as studied at intervals of 0, 10, 20 and 30 days. The drug was sprayed as 0.1 % concentration and repeated after 10 days for 3 times. The treatment was effective as density of mites was reduced from 201.2 mites / cm² to 105.2 mites / cm² 10 days after the first treatment and to 40.4 mites /cm² after 10 days of the second treatment then no mites observed after the third application. Itching and scratching were reduced on the 20th day of treatment, while complete recovery was observed after 30 days post treatment.