Dexamethasone sodium phosphate (0.13 mg/kg b. wt) and diclofenac sodium (6.7 mg/kg kg b.wt.) were injected intramuscularly day after day for two weeks to two groups of mature male rats respectively. After the end of the experiment, all rats of the treated and control groups were killed and blood samples were collected. Testosterone, corticosteroids prolactin, sodium and potassium levels were determined in the serum.Dexamethasone and diclofenac sodium significantly decreased testosterone level whereas, they elicited a significant increase in the levels of corticosteroids and prolactin. Serum sodium and potassium showed a significant increase and decrease as a result of treatment with dexamethasone and diclofenac respectively.