Gamma glutamyl transferase (GGT) and true cholinesterase, as well as each of the amino acids (glutamine, aspartic acid, glutamic acid, glycine, tyrosine, phenylalanine, histidine and tryptophan), except for gamma amino butyric acid (GABA) activity were significantly increased P≤0.001 in cerebrospinal fluid (CSF) of patients with bacterial meningitis (B.M). No change was observed in CSF electrolytes such as Sodium, calcium and magnesium except for potassium which was significantly increased P≤0.001 in patients with B.M as compared to healthy controls. Serum GGT activity was significantly elevated P≤0.001 in patients while serum true cholinesterase activity was significantly decreased p≤0.05 in patients with B.M. No change was observed in serum amino acids in patients with B.M as compared to healthy controls.