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185049

SYNTHESIS AND BIOLOGICAL ACTIVITY OF CERTAIN FLURBIPROFEN DERIVATIVES

Article

Last updated: 22 Jan 2023

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Abstract

The synthesis of several flurbiprofen amides and hydrazones is described. Structures of the new compounds were substantiated by microanalytical and spectroscopic data. Five representative compounds were subjected to preliminary pharmacological screening which revealed that three of them exhibited superior analgesic, antipyretic and anti-inflammatory activities compared to flurbiprofen.

DOI

10.21608/zjps.1996.185049

Authors

First Name

Mohamed

Last Name

El-Sadek

MiddleName

-

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt

Email

mmel-sadek@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Lobna

Last Name

Abdel-Aziz

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt

Email

lmabdel-aziz@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Kamel

Last Name

Abdel-Rahem

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, University of Zagazig, Egypt.

Email

kmabdel-rahem@pharmacy.zu.edu.eg

City

-

Orcid

-

Volume

5

Article Issue

1

Related Issue

24769

Issue Date

1996-06-01

Receive Date

1996-01-20

Publish Date

1996-06-01

Page Start

29

Page End

35

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 5_Issue 1_Pages 29-35.pdf

PDF . 4.8MB

Link

https://zjps.journals.ekb.eg/article_185049.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=185049

Order

4

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

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Article

Created At

22 Jan 2023