Hyperglycemia has a role in development of tissue hypoxia, a reasonable and a significant factor in atherogenesis. The persent study evaluates this diabetic complications through determination of Glycosylated hemogiobin AI (GHBA1), total cholesterol (Tc), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC), triglyceride (TG), malondialdehyde in erythrocytes membrane (RBCS MDA), Lipoprotein (a) Lp(a)), platelet cholesterol/phospholipid ratio (C/P ratio), fibrinogen, antithrombin II (AT III) and plasminogen. Streptozotocin (STZ) diabetic rats were compared with normal rats. STZ induced significant increase in glucose, GHBA1, Tc, LDLC, Lp(a), RBCS MDA, fibrinogen, plasmirgen and C/P ratio. On the other hand, it significantly decreased the HDLc and AT III This study aimed to correlate blood coagulation factors and changes in lipid and lipoproteins in diabetes mellitus.