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184960

PREPARATION AND EVALUATION OF IN VITRO DISSOLUTION CHARACTERISTICS OF SUSTAINED RELEASE METOPROLOL TARTRATE MICROCAPSULES

Article

Last updated: 22 Jan 2023

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Abstract

Metoprolol tartrate (MT) was encapsulated with Eudragit RS® by an emulsion-solvent evaporation method to develop a controlled release dosage form. This process was efficient, reproducible and not time consuming. Different release characteristics were obtained by changing the drug to polymer ratio and varying the percentage of aluminum tristearate incorporated in the encapsulation medium as a smoothing agent. In the presence of aluminum tristearate, the formed microcapsules were typically spherical and exhibited size distribution within a narrow range. High drug-to-polymer ratio resulted in increased microcapsule size and drug release rate. The microcapsules showed pH-independent dissolution behaviour.

DOI

10.21608/zjps.1997.184960

Authors

First Name

Mohammed

Last Name

El-Sayed

MiddleName

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Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University , Egypt

Email

mmel-sayed@pharmacy.zu.edu.eg

City

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Orcid

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Volume

6

Article Issue

1

Related Issue

24767

Issue Date

1997-06-01

Receive Date

1997-04-14

Publish Date

1997-06-01

Page Start

99

Page End

104

Print ISSN

1110-5089

Online ISSN

2356-9786

Link

https://zjps.journals.ekb.eg/article_184960.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=184960

Order

14

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

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Article

Created At

22 Jan 2023