Beta
ManageSearchChatDiscover
169709

UTILITY OF 2- HYDRAZIN04,6 DIMETHYLPYRIMIDINE IN HETEROCY CLIC SYNTHESIS

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

2-Hydrazino-4,6-dimethy1pyridine (1) readily underwent ring closure with benzoy1 chloride to give 5,7 dimethy1-3-pheny1-1,2,4-triazolo[4,3,-a]pyrimidine (4a). Either N-benzoyl derivative (2) or the hydrazone (3a) can be used for the formation of compound 4a. Reaction of compound 1 with acetylacetone gave the pyrazole derivative (6) rather than 1.2.4 triazepine derivative (5).The pyrrole (8) was the sole product from cyclization of 1 with 2.5- hexanedione. Reaction of compound 1 with carbon disulphide or ethy1 chloroformate gave 1,2,4-triazolo[4,3-a]pyrimidines (9 and 11) respectively . The reaction of thiosemicarbazides (12 a-c) with ethy1 bromoacetate and DCCD was investigated.

DOI

10.21608/zjps.1997.169709

Authors

First Name

Mohamed

Last Name

AL Ashmawy

MiddleName

-

Affiliation

Department of Organic Pharmaceutical Chemistry, Facutly of Pharmacy Zagazig University. Zagazig Egypt

Email

mial-ashmawy@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Zakaria

Last Name

Abd El-Samii

MiddleName

-

Affiliation

Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

zkabd-el-samii@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Said

Last Name

El-Feky

MiddleName

-

Affiliation

Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

sael-feky@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Nermin

Last Name

Osman

MiddleName

-

Affiliation

Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

naosman@pharmacy.zu.edu.eg

City

-

Orcid

-

Volume

6

Article Issue

1

Related Issue

24767

Issue Date

1997-06-01

Receive Date

1997-04-06

Publish Date

1997-06-01

Page Start

1

Page End

6

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 6_Issue 1_Pages 1-6.pdf

PDF . 3.3MB

Link

https://zjps.journals.ekb.eg/article_169709.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=169709

Order

1

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

MainTitle

UTILITY OF 2- HYDRAZIN04,6 DIMETHYLPYRIMIDINE IN HETEROCY CLIC SYNTHESIS

Details

Type

Article

Created At

22 Jan 2023