184804

SPECTROPHOTOMETRIC ESTIMATION OF METOCLOPRAMIDE HYDROCHLORIDE IN PHARMACEUTICAL PREPARATIONS

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Last updated: 04 Jan 2025

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Abstract

Two spectrophotometric methods were developed for the quantitative determination of metoclopramide hydrochloride and its dosage forms. The first method (method I) 1s based upon the interaction of the drug with 3-methyl benzothiazolinone-2-hydrazone (MBTH) in the presence of ferric chloride as an oxidizing agent, where a violet colour is formed that measured at A 555 nm in an aqueous media. The second method (method II) is based upon the interaction of the chloroformic extract of the drug free base, after alkalinization with 1,3-dinitrobenzene (DNB), where a charge-transfer complex product is formed that measured at 2 381 nm in chloroform The two proposed methods are accurate, sensitive, reproducible and applicable for the analysis of metoclopramide in the pure from and in its dosage forms (tablets and injections). The results obtained are compared with those of the titrimetric and UV measurement official B.P. 1998 method showing good agreement.

DOI

10.21608/zjps.1998.184804

Authors

First Name

Sobhy

Last Name

EI-Adl

MiddleName

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Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt.

Email

smei-adl@pharmacy.zu.edu.eg

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Orcid

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First Name

Mohamed

Last Name

Baraka

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

mmbaraka@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Osama

Last Name

El-Sabbagh

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

oiel-sabbagh@pharmacy.zu.edu.eg

City

-

Orcid

-

Volume

7

Article Issue

2

Related Issue

24766

Issue Date

1998-12-01

Receive Date

1998-10-19

Publish Date

1998-12-01

Page Start

80

Page End

85

Print ISSN

1110-5089

Online ISSN

2356-9786

Link

https://zjps.journals.ekb.eg/article_184804.html

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https://zjps.journals.ekb.eg/service?article_code=184804

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11

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

MainTitle

SPECTROPHOTOMETRIC ESTIMATION OF METOCLOPRAMIDE HYDROCHLORIDE IN PHARMACEUTICAL PREPARATIONS

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Article

Created At

22 Jan 2023