In this study, the effects of albendazole (10 mg/kg b.wt.) on some hormonal, haematological and biochemical profiles of 20 mature sheep of both sex were studied after its oral administration as 2.5 % suspension. Albendazole exerted a significant increase in the levels of serum globulins, alanine aminotransferase (ALT),aspartate aminotransferase (AST), superoxide dismutase (SOD), total leukocytic count (WBCS) and their differential count, particularly lymphocytes and neutrophils. Moreover, it evoked a significant decrease in serum testosterone of rams. Meanwhile, it demonstrated no significant effect on the levels of estradiol and progesterone in ewes.