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184818

SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL HETEROCYCLIC DERIVATIVES OF FLURBIPROFEN

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Last updated: 22 Jan 2023

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Abstract

The synthesis of some novel non- carboxylic heterocyclic derivatives of flurbiprofen such as pyrazole , pyrrole , oxadiazole, oxadiazines, and triazoles, is described. Structure of the new compounds was elucidated by spectroscopic data and microanalysis. Three representative compounds were tested for analgesic, antipyretic, and anti-inflammatory activities. The pyrazole derivative VIII displayed greater antipyretic activity but lower analgesic and anti-inflammatory activities compared to flurbiprofen. However, the other two compounds were , in general, less potent than flurbiprofen.

DOI

10.21608/zjps.1998.184818

Authors

First Name

Mohamed

Last Name

El-Sadek

MiddleName

-

Affiliation

Dept. of Medicinal Chemistry, Faculty of Pharmacy, University of Zagazig, Zagazig , Egypt

Email

meel-sadek@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Lobna

Last Name

Abdel-Aziz

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt

Email

lmabdel-aziz@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Mansour

Last Name

Abou-Kull

MiddleName

-

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt

Email

meabou-kull@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Kamel

Last Name

Metwally

MiddleName

-

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig. Egypt

Email

kametwally@pharmacy.zu.edu.eg

City

-

Orcid

-

Volume

7

Article Issue

1

Related Issue

24765

Issue Date

1998-06-01

Receive Date

1998-04-09

Publish Date

1998-06-01

Page Start

94

Page End

100

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 7_Issue 1_Pages 94-100.pdf

PDF . 4.3MB

Link

https://zjps.journals.ekb.eg/article_184818.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=184818

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Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

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Article

Created At

22 Jan 2023