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184167

SPECTROPHOTOMETRIC ESTIMATION OF SOME NITROGENOUS PHARMACEUTICAL COMPOUNDS BY CHARGE TRANSFER COMPLEXATION

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Last updated: 22 Jan 2023

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Abstract

Three simple and sensitive colorimetric methods have been developed for the estimation of trazodone, timolol and piribedil through electron transfer complexation reaction. The methods involve the reaction of these drugs as p-donors with either n-electron acceptors P-chloronilic acid (PCA) and tetracyano-quinodimethane (TCNQ) and iodine as acceptor to give a stable and highly coloured radical anion. The coloured products were measured spectrophotometrically. The optimization of the different experimental conditions has been studied. The suggested methods were applied to assay the tested compounds in their pharmaceutical preparations. The results obtained agreed well with the reference methods.

DOI

10.21608/zjps.1999.184167

Authors

First Name

Magda

Last Name

Ayad

MiddleName

-

Affiliation

Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University. Zagazig. Egypt.

Email

mmayad@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Hawa

Last Name

Khalil

MiddleName

-

Affiliation

Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

hmkhalil@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Magda

Last Name

El-Henawee

MiddleName

-

Affiliation

Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig. Egypt

Email

mmel-henawee@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Mervat

Last Name

Hosny

MiddleName

-

Affiliation

Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University. Zagazig. Egypt.

Email

mmhosny@pharmacy.zu.edu.eg

City

-

Orcid

-

Volume

8

Article Issue

1

Related Issue

24763

Issue Date

1999-06-01

Receive Date

1999-04-14

Publish Date

1999-06-01

Page Start

60

Page End

67

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 8_Issue 1_Pages 60-67.pdf

PDF . 4.2MB

Link

https://zjps.journals.ekb.eg/article_184167.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=184167

Order

8

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

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Article

Created At

22 Jan 2023