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184165

NUCLEOPHILIC CLEAVAGE OF N-SUBSTITUTED -3- OXO- 2,3- DIHYDRO BENZO (d) - 1,2 -THIAZOLE-1,1-DIOXIDE WITH HYDRAZINE HYDRATE

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Last updated: 04 Jan 2025

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Abstract

The reaction profile of certain 2-substituted-3-oxo-2,3- dihydrobenzo (d)-1,2- thiazole-1,1-dioxide (N-substitued saccharines) with hydrazine hydrate is described. It was found that the steric hindrance displayed by the substituents at position-2 has a profound effect on reaction rate. Some of the synthesized compounds were subjected to preliminary antimicrobial activity.

DOI

10.21608/zjps.1999.184165

Authors

First Name

Mohamed

Last Name

Al-Ashmawi

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

mial-ashmawi@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Lobna

Last Name

Abdel-Aziz

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, University of Zagazig, Zagazig -Egypt.

Email

laabdel-aziz@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Samia

Last Name

Mustafa

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, University of Zagazig, Zagazig -Egypt.

Email

samia.mustafa@yahoo.com

City

-

Orcid

-

Volume

8

Article Issue

1

Related Issue

24763

Issue Date

1999-06-01

Receive Date

1999-03-14

Publish Date

1999-06-01

Page Start

47

Page End

52

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 8_Issue 1_Pages 47-52.pdf

PDF . 2.6MB

Link

https://zjps.journals.ekb.eg/article_184165.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=184165

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Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

MainTitle

NUCLEOPHILIC CLEAVAGE OF N-SUBSTITUTED -3- OXO- 2,3- DIHYDRO BENZO (d) - 1,2 -THIAZOLE-1,1-DIOXIDE WITH HYDRAZINE HYDRATE

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Article

Created At

22 Jan 2023