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UTILIZATION OF α-BROMOCYCLIC DIKETONES AS MICHAEL DONORS FOR THE SYNTHESIS OF COUMARIN ANALOGUES

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Last updated: 04 Jan 2025

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Abstract

Coumarin nucleus is of biological importance. Anticoagulants which are very common contain coumarin moiety. Herein we describe a facile method to prepare this valuable nucleus. α-Bromocyclic diketones were used as Michael donors and each reacted with various substituted acrylonitriles, which behaved as Michael acceptors. Elimination of hydrobromic acid leads to the formation of the target compounds (17-30) in reasonable yields.

DOI

10.21608/zjps.2000.181616

Authors

First Name

Magdy

Last Name

El-Sawah

MiddleName

-

Affiliation

Department of Pharmaceutical Org. Chem., Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

mel-sawah@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

El-Bermawy

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

mael-bermawy@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Eatedal

Last Name

Abdel-Aal

MiddleName

-

Affiliation

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

Email

ehabdel-aal@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Azza

Last Name

Kadry

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

amkadry@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Al-Ashmawi

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

mial-ashmawi@pharmacy.zu.edu.eg

City

-

Orcid

-

Volume

9

Article Issue

2

Related Issue

24762

Issue Date

2000-12-01

Receive Date

2000-10-12

Publish Date

2000-12-01

Page Start

50

Page End

53

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 9_Issue 2_Pages 50-53.pdf

PDF . 1.7MB

Link

https://zjps.journals.ekb.eg/article_181616.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=181616

Order

8

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

MainTitle

UTILIZATION OF α-BROMOCYCLIC DIKETONES AS MICHAEL DONORS FOR THE SYNTHESIS OF COUMARIN ANALOGUES

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Article

Created At

22 Jan 2023