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181592

IBUPROFEN-QUERCETIN COMBINATION ASA NOVEL PHARMACEUTICAL COMPATIBLE SYSTEM

Article

Last updated: 22 Jan 2023

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Abstract

The effect of oral administration of quercetin (QRT) (25 mg/kg) on an experimentally Ibuprofen- induced ulcer was studied in rats. The results of gross appearance and scanning electromicrographs of the mucous membrane and superficial cells of the stomach revealed that the quercetin reduced the damage of submucosal superficial cells. Differential scanning calorimetry, X-ray diffractometer, IR spectroscopy, solubility and partitioning studies elucidated the absence of any interaction between the two compounds and also the physical compatibility of ibuprofen (IP)-quercetin combination. It is concluded that ibuprofen and quercetin can be pharmaceutically co-formulated or co-administrated with the aim of reducing the gastrointestinal adverse effects of ibuprofen.

DOI

10.21608/zjps.2001.181592

Authors

First Name

Mohamed

Last Name

Abdel Mohsen

MiddleName

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Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt.

Email

mohamed.abdel-mohsen@yahoo.com

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First Name

Mahmoud

Last Name

El-Badry

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt.

Email

mahmoud.el-badry@yahoo.com

City

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Orcid

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First Name

Osama

Last Name

Soliman

MiddleName

-

Affiliation

Department of Pharmaceutics Faculty of pharmacy. Mansoura University, Mansour. 35516. Egypt.

Email

osama.soliman@yahoo.com

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Volume

10

Article Issue

1

Related Issue

24759

Issue Date

2001-06-01

Receive Date

2001-04-08

Publish Date

2001-06-01

Page Start

29

Page End

33

Print ISSN

1110-5089

Online ISSN

2356-9786

Link

https://zjps.journals.ekb.eg/article_181592.html

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https://zjps.journals.ekb.eg/service?article_code=181592

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6

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

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Article

Created At

22 Jan 2023