178029

SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF LISINOPRIL IN PHARMACEUTICAL FORMULATION

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Last updated: 04 Jan 2025

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Abstract

Three simple and sensitive spectrophotometric methods for the determination of lisinopril in tablets are developed. The first method involves oxidation of lisinopril with 1-chlorobenzotriazole reagent (CBT) in strong alkaline medium followed by measuring the absorbance at 350 nm. The method obeys Beer\\''s law over concentration range 8-64 µg ml-1 with mean recovery 99.28±1.088. The second method involves the reaction of the primary amino group of lisinopril with ninhydrin reagent producing a coloured product with absorbance maximum at 564 nm. The linearity range was found to be 4 - 20 µgml-1 with mean recovery 99.09±1.069.The third method is based on the coupling reaction with 1,2-naphthaquinone-4-sulphonate (NQS) to form a coloured product (ʎmax: 305). Regression analysis of a Beer''s plot showed good correlation in concentration 4-24 µg ml-1 with mean recovery 99.40± 0.891. The optimum experimental parameters for the reactions have been studied and the reactions mechanisms are discussed. The validity of the described procedures was assessed. Statistical analysis of the results has been carried out revealing high accuracy and good precision. The suggested procedures could be used for the determination of lisinopril in tablets. The procedures were rapid, simple and sensitive for quality control application.

Authors

First Name

Hisham

Last Name

Abdellatef

MiddleName

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Affiliation

Analytical Chemistry Department , Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

Email

heabdellatef@pharmacy.zu.edu.eg

City

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Orcid

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First Name

Magda

Last Name

El-Henawee

MiddleName

-

Affiliation

Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig. Egypt

Email

mmel-henawee@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Heba

Last Name

El-Sayed

MiddleName

-

Affiliation

Analytical Chemistry, Faculty of Pharmacy, Department of Zagazig University - Zagazig - Egypt

Email

hmel-sayed@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Magda

Last Name

Ayad

MiddleName

-

Affiliation

Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University. Zagazig. Egypt.

Email

mmayad@pharmacy.zu.edu.eg

City

-

Orcid

-

Volume

12

Article Issue

2

Related Issue

24756

Issue Date

2003-12-01

Receive Date

2003-07-16

Publish Date

2003-12-01

Page Start

6

Page End

10

Print ISSN

1110-5089

Online ISSN

2356-9786

Link

https://zjps.journals.ekb.eg/article_178029.html

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https://zjps.journals.ekb.eg/service?article_code=178029

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2

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Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

MainTitle

SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF LISINOPRIL IN PHARMACEUTICAL FORMULATION

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Article

Created At

22 Jan 2023