A new series of 2,3-dihydro-4(1H)-quinazolinones was synthesized by condensation of 2-methylamino-N-substituted benzamides (III) with either formaldehyde or aromatic aldehydes to produce 2,3-dihydro-1-methyl-3-(substituted phenyl)-4(1H) -quinazolinones (V) and 2,3-dihydro-2,3-di(substituted phenyl)-1-methyl-4(1H)-quinazolinones (VI) respectively.
The anti-inflammatory study of some of the prepared compounds revealed that compound (Vla) showed significant activity in comparison with flufenamic acid.