Four isoflavones (glabrisoflavone, prunitin, santal and genisetin), two flavonols (kaempferol and quercetin) and one phenolic acid (4-hydroxy phenyl acetic acid) beside β-sitosterol and ß-sitosterol-O-glucoside, were isolated from the aerial parts of the Egyptian licorice (G. glabra). Santal, 4-hydroxy phenyl acetic acid and B-sitosterol-O-glucoside are reported here for the first time in the genus Glycyrrhiza. The structures of the isolated compounds were determined by IR, UV, MS, ¹H-NMR and ¹³CNMR (2D experiments), as well as comparison with reference samples. Preliminary pharmacological testing of the total alcoholic extract and some of its fractions demonstrated potent anti-inflammatory and hepato-protective activities compared to hydrocortisone and silymarin, respectively.