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177894

SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF SOME NOVEL THIENOPYRIMIDINE DERIVATIVES

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Last updated: 22 Jan 2023

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Abstract

4-Chloro-5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidine (3) was reacted with 4-aminoacetophenone in ethanol to give 4(4- acetylanilino)5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidine (4). Compound 4 was used as a key intermediate for the synthesis of several pyrazoles 6-8, pyridones 13, 14, thiazoles 15, 17 and thiazolidinones 18, 19. On the other hand, compound 3 was fused with ethyl 2-amino-4,5,6,7-tetrahydrobenzofbthiophene-3-carboxylate and anthranilic acid to give compound 9 and 10 respectively. Compound 14b showed the same antiinflammatory activity as that of the reference drug dichlofenac sodium.

DOI

10.21608/zjps.2004.177894

Authors

First Name

Zakaria

Last Name

Abd El-Samii

MiddleName

-

Affiliation

Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

zkabd-el-samii@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Said

Last Name

El-Feky

MiddleName

-

Affiliation

Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

sael-feky@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Hanan

Last Name

Abedel-Fattah

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

haabedel-fattah@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Mahmoud

Last Name

Soliman

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

mesoliman@pharmacy.zu.edu.eg

City

-

Orcid

-

Volume

13

Article Issue

2

Related Issue

24754

Issue Date

2004-12-01

Receive Date

2004-07-07

Publish Date

2004-12-01

Page Start

6

Page End

15

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 13_Issue 2_Pages 6-15.pdf

PDF . 3.9MB

Link

https://zjps.journals.ekb.eg/article_177894.html

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https://zjps.journals.ekb.eg/service?article_code=177894

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2

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Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

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Article

Created At

22 Jan 2023