This study a carried out to investigate the importance of Carcia papaya fruit and its leaves as an antidiabetic agent. The glucose and fructose contents of papaya fruit were determined using HPLC technique .The effect of fruit (10 & 20%) and leaves(5&10%) on food efficiency ratio, body weight gain, hiver weight, kidney weight. blood glucose, cholesterol, triglycerides, uric acid and creatinine levels were determined in alloxan-induced diabetic rats. Fourteen days treatment with Carica papaya showed considerable lowering in blood glucose level, no significant changes in serum cholesterol and triglyceride, decreasing in uric acid and creatinine levels m the treated diabetic group under investigation. Fruit and leaves showed phenolic contents and potential reducing  power as indicator for antioxidative activity. These results suggest that Carica papaya fruit and leaves posses antidiabetic effects in alloxan-induced diabetic rats, while no hypolipidemic effects were observed .The amelioration in the blood glucose level and other physiological organs may be due in part to the antioxidant activity of Carcia papaya fruits and leaves.