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169424

SYNTHESIS OF CERTAIN NOVEL PYRIDOTHIOPYRANOQUINOLINES AS POTENTIAL ANTICANCER AGENTS

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Last updated: 22 Jan 2023

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Abstract

A series of ethyl 2-substituted aminopyrido [3',2': 5,6] thiopyrano [ 4,3,2-de] quinoline-1-carboxylate (VII)i-viii was obtained by reacting ethyl2-chloropyrido[3',2':5,6] thiopyrano [4,3,2-de] quinoline-1-carboxylate (VIa) with certain aromatic amines. Another series of ethyl 6-chloro-9,11-dimethyl-2-substituted aminopyrdo [3',2':5,6] thiopyrano [ 4,3,2-de] quinoline-1-carboxylate (VIIb)i-viii was also obtained by reacting ethyl 2,6-dichloro-9,11-dimethylpyrido [3',2':5,6] thiopyrano[4,3,2-de] quinoline-1-carboxylate  )VIb) with different amines. Molecular modeling study and in vitro cytotoxic effect of some samples of the synthesized compounds were also achieved.

DOI

10.21608/zjps.2006.169424

Authors

First Name

Khaled

Last Name

El-Shemy

MiddleName

-

Affiliation

Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo

Email

khaled.el-shemy@yahoo.com

City

-

Orcid

-

First Name

Osama

Last Name

El-Badry

MiddleName

-

Affiliation

Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo

Email

osama.el-badry@yahoo.com

City

-

Orcid

-

First Name

Sameha

Last Name

Roshdy

MiddleName

-

Affiliation

Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo

Email

sameha.roshdy@yahoo.com

City

-

Orcid

-

First Name

Mervat

Last Name

El-Enany

MiddleName

-

Affiliation

Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo

Email

mervat.el-enany@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Ismail

MiddleName

-

Affiliation

Medicinal Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt

Email

mohamed.ismail@yahoo.com

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-

Orcid

-

Volume

15

Article Issue

2

Related Issue

24703

Issue Date

2006-12-01

Receive Date

2006-09-23

Publish Date

2006-12-01

Page Start

29

Page End

37

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 15_Issue 2_Pages 29-37.pdf

PDF . 2.3MB

Link

https://zjps.journals.ekb.eg/article_169424.html

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https://zjps.journals.ekb.eg/service?article_code=169424

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Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

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Article

Created At

22 Jan 2023