Two simple, sensitive and accurate spectrophotometric methods have been established for the determination of clidinium bromide (CBr), ambroxol hydrochloride (AX) and tramadol hydrochloride (TD) using methyl orange (MO) and bromocresol  purple (BCP) The proposed methods consist of extracting the formed ion-associates into methylene chloride in the case of (CBr and AX) using MO or of (TD) using BCP and into chloroform in case of (TD) using MO or of (CBr and AX) using BCP .The ion-associates exhibit absorption maxima at 425, 424 and 427 nm for MO and 415, 412, 410 nm using BCP with CBr ,AX and TD, respectively Beer's law was obeyed in the concentration ranges 20-34 µg ml^-1. The molar absorptivity, Sandell sensitivity of the reaction products were calculated detection and quantification limits were also calculated The correlation coefficient was ≥0.9987 with a relative standard deviation (R.S D.) of ≤ 1.054 of six determinations for 10 µg ml^-1 . The method was applied to the determination of the drugs in their pure state or pharmaceutical preparations and compared statistically using the Official methods.