The buccoadhesive tablets of Chlorpheniramine Maleate (CPM) were prepared using bioadhesive polymers as sodium Carboxymethy1 cellulose (NACMC), sodium alginate. Hydroxyethy1cellulose (HEC). and hydroxypropylmethy1 cellulose (HPMC) in different drug to polymer ratios. The CPM buccoadhesive tablet formulae were subjected to in-vitro permeation studies at pH 6.8 (pH of the buccal medium) using chicken pouch membrane. The effect of permeation enhancers, namely. menthol, sodium lauryl sulphate and sodium salicylate as 5% concentrations, on the in-vitro permeation of CPM from buccoadhesive tablet formulae were studied. The permeation parameters like permeability coefficient (P, cm/hr), diffusion coefficient (D, cm²/hr) and the enhancement factor (EF) were calculated according to Fick's first law of diffusion. The quality control tests like, disintegration, hardness, friability and weight uniformity were done and the results were compared before and after the addition of permeation enhancers, using analysis of variance test (ANOVA). It was concluded that the permeation enhancing effect of menthol 5% on CPM permeation from all the buccoadhesive tablet formulae is promising, since the conditions applied experimentally in this work mimic to a large extent that presence in the buccal region could reflect the drug behavior towards human buccal membrane.