Beta
ManageSearchChatDiscover
169370

SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL PYRAZOLE DERIVATIVES

Article

Last updated: 22 Jan 2023

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

The key intermediate, 5-(p-chloropheny1)-1H-pyrazole-3-carboxylic acid hydrazide (3),was used for the synthesis of some new hydrazones 8a-g as well as some five membered heterocyclic derivatives such as pyrazoles 10, 11a,b, 12, pyrrole 13, 1,3,4-Oxadiazole 15, 1,2,4-triazole 17 and 1,3,4-thiadiazole 19. Identification of the new compounds was substantiated by spectral data and elemental analysis .Compound 6f which has a sulfadiazine moiety linked to the pyrazole showed a powerful anti-inflammatory activity than diclofenac sodium.

DOI

10.21608/zjps.2007.169370

Authors

First Name

Zakaria

Last Name

Abd El-Samii

MiddleName

-

Affiliation

Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

zkabd-el-samii@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Said

Last Name

El-Feky

MiddleName

-

Affiliation

Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

sael-feky@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Nermin

Last Name

Osman

MiddleName

-

Affiliation

Department of Organic Pharmaceutical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

naosman@pharmacy.zu.edu.eg

City

-

Orcid

-

Volume

16

Article Issue

1

Related Issue

24700

Issue Date

2007-06-01

Receive Date

2007-04-07

Publish Date

2007-06-01

Page Start

19

Page End

28

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 16_Issue 1_Pages 19-28.pdf

PDF . 2.9MB

Link

https://zjps.journals.ekb.eg/article_169370.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=169370

Order

3

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023