The present study deals with the changes induced by dimethoaie pesticides, which commonly used in Yemen especially in khat plant and other vegetables and fruits. Twenty of adult male rabbit. Were divided into three groups, the first one was served as control group. The rest administered 1/20 (1.34 mg. Kg. b.wt.) and (1/1) (2.68 mg. kg. b.wt.) of LD₅₀ of pesticides respectively. All Animals were housed in separate cages under standard condition and stayed for two weeks before starting the experiments. The results revealed structural changes which more sever in rabbits given high doses of pesticide especially in liver and testes. The liver showed degenerative changes of hepatic cells and focal necrotic hepatocytes with lymphocytic infiltration and destructive of bile ducts lining epithelium in addition to congestion and widening of sinosoides and hepatic venules. The seminiferous tubules of the testes showed a considerable atrophy associated with marked reduction of spermatogonial cell number, partial failur of spermatogenesis was clearly detached. The spermatogonial cells revealed pyknotic nuclei, sertoli cells were detached from the basal lamina. The spermatids were undergoing several degenerative changes involved shrinkage or collaps of chromatin. The kidney tissue showed renal oedema and focal areas of tubular necroses and high vacuclated cytoplasm.