A controlled trial was conducted to compare the current efficacy of ivermectin plus clorsulon( Alfameetin super®) and nitroxynil (Tronex®) against Fasciola gigantica in naturally infested cattle. This trial was conducted in Sharkia Provinee. Twenty Four male Frezian cattle (18-24) months old and ranged from (150-180) kgm /animal were selected based on finding eggs of E gigantica in  their faeces The cattle were weighted and randomly allotted into four groups each of 6 a nimal and treatments were as  follows : Group I served as non-tested non-treated control. Group 2 was naturally infested with E gigantica and non-treated. Group was infested and treated with ivermectin plus clorsulon at dose level of ImI/ 50 kg bwt administered subcutaneously (SC). and Group 4 was infested and received nitroxynil at dose level of ImI/ 25 kg bwt by SC injection. Individual faecal samples were collected before treatment (zero day) and on 1st. 2nd. 3rd and 4th week post treatment (PT), while blood samples were collected before treatment on zero day and on 7th, 14th and 28th day post treatment .The drug efficacy was assessed as a percentage of egg reduction (Faecal egg count reduction percent FECR %).Body weight was recorded on zero day and on 2nd 4th 6th and 8th week PL. Biochemical. haematological findings and body weight gain were recorded relative to the infested untreated control. The present results showed that FECR%, of group3 was 69.1 ±2.3, 87.3 ± 0 6, 94.5 ±0.2, and 100%,  while group4 showed that FECR% was 73.2 ±0.6, 90.2± 0.3 , 97.6 ±0.1  and 100% on 1st 2nd 3rd and 4th week post treatment (PT) respectively. There were no significant differences between the two drugs on liver and Kidney functions as well as blood picture In contrast, ivermectin plus clorsulon treated group showed more significant increase in body weight than nitroxynil treated group.